Pay in 4 interest-free payments of $31.50 Learn more
Ships within 48 hours · Estimated delivery Jul 27 - Aug 1
331244-89-4
5-a]pyrazine
this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC)
plasminogen activator inhibitor (PAI) 1
InChi: InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7
ARV 771 Size:10mg solid 331244-89-4Potent BET bromodomain PROTAC degrader (DC50 = < 1nM). Comprises a BRD4 binding moiety joined by a linker to a ligand for Von Hippel Lindau (VHL) protein. Degrades BRD2 3 4 in castration resistant prostate cancer (CRPC) cell lines. Reduces androgen receptor levels and induces apoptosis in CRPC cells in vitro. Down regulates BRD4 and induces tumor regression in CRPC xenografts in mice. Also reduces leukemia burden in a mouse model. Induces degradation