Allo-aca 3107 Glycogen synthase kinase-3β inhibition ameliorates

Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice

Chemical Name: 16-butan-2-yl-10

Smiles: CC(=O)N1CCN(CC1)C1C=CC(=CC=1)OC[C@@H]1CO[C@](CN2C=NC=C2)(O1)C1=CC=C(Cl)C=C1Cl |&1:17

It is also known to inhibit the epithelila-to-mesenchymal transition and suppresses LPS-stimulated production of pro-inflammatory cytokines in macrophages

2011 Aug 12

Allo-aca 3107 Glycogen synthase kinase-3β inhibition amelioratesAllo aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo aca blocks leptin signaling and action in numerous in vitro and in vivo models. Product information Molecular Weight: 1074. 19 Formula: C48H75N13O15 Chemical Name: (6S, 9S, 12S, 15S, 18S, 21S, 24S) 1 amino 6 ((4 (2 amino 2 oxoethyl) 2 oxo 2H chromen 7 yl)carbamoyl) 24 ((2S, 3R) 2 amino 3 hydroxybutanamido) 9 (hydroxymethyl) 1 imino 12 isobutyl 18