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66 nM unbound) based on terminal concentrations measured in the study animals (1
interleukin-6 (IL-6)
It can selectively promote the degradation of Vps34 complexes
Talatisamine
3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S
PF-04634817 Catalog No.:M21127-C 66 nM unbound) based onPF 0463481 is a potent and orally active dual CCR2 CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20. 8 nM), and displays 10 20 fold less rodent CCR5 potency (rat IC50=470 nM). PF 0463481 is safe and well tolerated and has the potential for the study of diabetic nephropathy. Product information CAS Number: 1228111 63 4 Molecular Weight: 511. 58 Formula: C25H36F3N5O3 Chemical Name: (3S,4S) 3 methoxy N [(1R,3S) 3 (propan 2 yl) 3
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