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Serum drug level measurements in satellite animals on the first day of dosing show that a single dose provides coverage for approximately 3 h (6 h daily with twice daily dosing) of the mouse whole-blood IC50 value against LPS-induced TNF-α
one of the earliest events in hepatic damage
442 (2002) 163-171
Maytansinol inhibits the growth of HCT116 human colon cancer cells
Formula: C28H24O2S
SAR-020106 22279 Serum drug level measurements inSAR 020106 is an ATP competitive, potent, and selective CHK1 inhibitor with an IC50 of 13. 3 nM for human CHK1. SAR 020106 shows excellent selectivity over CHK2. SAR 020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3 to 29 fold in several colon tumor lines and in a p53 dependent fashion. SAR 020106 can enhance antitumor activity with selected anticancer drugs. Product information CAS Number: 1184843 57 9 Molecular Weight: 382.
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