JNK-IN-8 - CAS# 1410880-22-6 60136 causing cell death that involves

causing cell death that involves the p38 stress kinase pathway and a bimodal cell cycle arrest

BGJ-398 shows a rapid distribution from the vascular compartment into the peripheral tissues

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which mediate their binding to acetylated lysine residues on histones and other proteins

JNK-IN-8 - CAS# 1410880-22-6 60136 causing cell death that involvesJNK IN 8, also known as JNK Inhibitor XVI, CAS No. 1410880 22 6, is a selective JNK inhibitor that inhibits phosphorylation of c Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway based profiling establish the selectivity of JNK IN 8 for JNK and suggests that the compound will be broadly useful as a