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Smiles: O=C1CCC(C2CCN(CC3C=CC(I)=CC=3)CC2)(C2C=CC=CC=2)C(=O)N1
8 nM (hCCR2) and 7
GLPG0187 at all concentrations significantly reduces cell proliferation
increasing AMPK phosphorylation and repressing the activation of CREB
Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry in these tumor cells
OSU-T315 - CAS# 2070015-22-2 Size:10mg solid Smiles: O=C1CCC(C2CCN(CC3C=CC(I)=CC=3)CC2)(C2C=CC=CC=2)C(=O)N1OSU T315 (ILK IN 1) is a small Integrin linked kinase (ILK) inhibitor with an IC50 of 0. 6 M, inhibiting PI3K AKT signaling by dephosphorylation of AKT Ser473 and other ILK targets (GSK 3 and myosin light chain). OSU T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase dependent apoptosis in an ILK independent manner[2]. OSU T315 causes cell death through apoptosis and autophagy. Product information CAS
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