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4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10
InChiKey: UICNBXVDHCBKCE-PUODRLBUSA-N
082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0
Molecular Weight: 108
allowing high liver drug exposure with only modest plasma drug exposure
CCT 031374 hydrobromide Catalog No.:M22781-C 4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10CCT 031374 hydrobromide is a selective inhibitor of Wnt catenin signaling pathway . The Wnt catenin pathway is activated by the binding of Wnt ligand to a complex comprising LRP5 6 and Frizzled (Fz) receptors and then activates transcription factor catenin dependent transcription . CCT 031374 hydrobromide is a selective Wnt catenin signaling pathway inhibitor. CCT031374 inhibited BIO induced catenin accumulation in L cells with IC50 value of 6. 1 M.
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