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It was launched in 1995
Smiles: C[C@@H](O)[C@H](NC(=O)C1=CC=C(C=C1)C#CC1=CC=C(CN2CCOCC2)C=C1)C(=O)NO
Molecular Weight: 172
and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3)
62(1):65–74
Folic acid Size:Solid 2 mg It was launched in 1995ABT 100 is an orally bioavailable farnesyltransferase inhibitor. ABT 100 inhibited proliferation of cells in vitro carrying oncogenic H Ras (EJ 1 bladder; IC(50) 2. 2 nmol L), Ki Ras (DLD 1 colon, MDA MB 231 breast, HCT 116 colon, and MiaPaCa 2 pancreatic; IC(50) range, 3. 8 9. 2 nmol L), and wild type Ras (PC 3 and DU 145; IC(50), 70 and 818 nmol L, respectively) as well as clonogenic potential. ABT 100 shows 70% to 80% oral bioavailability in mice.
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