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Solubility: DMSO 48 mg/mL (199
Chemical Name: N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3
RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
In vivo administration of LY-2157299 ameliorated anemia in a TGF-β overexpressing transgenic mouse model of bone marrow failure
PMID: 25657334
MK-5108 Size:Solid 2 mg Solubility: DMSO 48 mg/mL (199MK 5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora A kinase. MK 5108 specifically inhibited Aurora A kinase in a panel of protein kinase assays. MK 5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK 5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. MK 5108 is currently tested in clinical trials