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Hoflack JC
thereby inhibiting DNA replication and repair and RNA and protein synthesis
Epub 2014 Oct 29
Chemical Name: 2-{4-[(4S
Elliott WL
IPA-3 Size:2mg solid Hoflack JCIPA 3 is a potent and selective PAK1 inhibitor. IPA 3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF B activation. IPA 3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA 3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF B. IPA 3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse