WH-4-023 denafil Hydrochloride it exhibits much less activity

it exhibits much less activity against unrelated RTKs

Smiles: CO[C@@H]1[C@@H](CO)O[C@H]([C@@H]1O)N1C=NC2=C1NC(N)=NC2=O

23)18(27)10-20(16

1 100 PMID: 30271980

Smiles: CC1=CC=C(N)C=C1C(=O)N[C@H](C)C1=CC=CC2=CC=CC=C21

WH-4-023 denafil Hydrochloride it exhibits much less activityWH 4 023 is a potent and selective dual Lck Src inhibitor with IC50 of 2 nM 6 nM for Lck and Src kinase respectively. The lymphocyte specific kinase ( Lck ) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and NK cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Product