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Molecular Weight: 1607
Calvert AH
Selectivity testing against a panel of 7 transmembrane domain receptors indicated that BX 513 is inactive on a number of receptors at concentrations up to 10 μM
Formula: C11H14O4
Chemical Name: N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-5-({6-[(methylamino)methyl]pyrimidin-4-yl}oxy)-1H-indole-1-carboxamide
EGFR-IN-1 14 mesylate Molecular Weight: 1607EGFR IN 1 (compound 24) is an orally active and irreversible L858R T790M mutant selective EGFR inhibitor. EGFR IN 1 potently inhibits Gefitinib resistant EGFR L858R, T790M with 100 fold selectivity over wild type EGFR. EGFR IN 1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. Product information CAS Number: 1625677 63 5 Molecular Weight: 514. 58 Formula: C28H30N6O4 Chemical
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