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Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 Smiles: BrC1=C2N=CC=NC2=CC=C1NC1NCCN=1

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Description

Smiles: BrC1=C2N=CC=NC2=CC=C1NC1NCCN=1

S0859 reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1

CGS 21680A is the hydrochloride salt

InChiKey: VJYKVCURWJGLPG-IQZGDKDPSA-N

4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3

Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 Smiles: BrC1=C2N=CC=NC2=CC=C1NC1NCCN=1Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models

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