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2-Methoxyestradiol inhibits proliferation of MCF-7 and BM cells with IC50 of 52 μM and 8 μM
) in a model of puromycin aminonucleoside-induced renal fibrosis
OTS514 (1-5 mg/kg
increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage
Smiles: CC(C)C[C@H](NC(=O)[C@@H](NC(=O)C1=CC=CC(=N1)C1C=CC=CC=1)[C@@H](C)O)B(O)O
SNIPER(ER)-87 Catalog No.:M7563-10 2-Methoxyestradiol inhibits proliferation of MCF-7SNIPER(ER) 87 is a potent and selective estrogen receptor (ER) Degrader (Specific and Nongenetic IAP dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER) 87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen binding moiety 4 hydroxytamoxifen (Cat. No. 3412). The product decreases ER levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER) 87 also reduces ER levels and inhibits
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