CASIN - Cdc42 Inhibitor. CAS# 425399-05-9 size:2 mg solid It inhibited Hh signaling and

It inhibited Hh signaling and induces tumor regression in animal models of medulloblastoma

and HDAC6 in cell-free assays

There is a pocket on SUMO E1 likely to be responsible for N106's effect

Connolly EC

9 μM) with respect to [125I]iodo-palmitoyl CoA

CASIN - Cdc42 Inhibitor. CAS# 425399-05-9 size:2 mg solid It inhibited Hh signaling andCASIN, CAS No. 425399 05 9, is a novel and potent Cdc42 inhibitor with an IC50 ~2 M. In a recent publication in Cell Stem Cell, the elevated activity of the small RhoGTPase Cdc42 in aged HSCs was shown to be causally linked to HSC aging and correlate with a loss of polarity in aged HSCs. CASIN as a specific inhibitor of Cdc42 was shown to functionally rejuvenate aged HSCs, increase the percentage of polarized cells in an aged HSC population, and