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3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide
when added to human plasma
3 μM) but not p110α/p85α PI3K (IC50>100 μM)
This inhibition of MEK1/2 is noncompetitive with ERK and ATP
700874-72-2
SB-743921 HCl Catalog No.:M7949-2 3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamideSB 743921 is a synthetic small molecule with potential antineoplastic properties. SB 743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. Product information CAS Number: 940929 33 9