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a p38 mitogen-activated protein-kinase inhibitor
2017 Jan 6
In the human CLL NSG xenograft model
CAS Number: 11021-14-0
Smiles: CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOC2C=CC(=CC=2)C2=CC3=C(NC4=CC(Cl)=C(C=C4)OCC4=CC(F)=CC=C4)N=CN=C3C=C2)C(C)(C)C)C=C1
Volasertib Catalog No.:M10873-10 a p38 mitogen-activated protein-kinase inhibitorVolasertib, also known as BI 6727, is a dihydropteridinone Polo like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. BI 6727 selectively inhibits Plk1, inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. BI 6727 is highly potent (enzyme IC(50) = 0. 87 nmol L, EC(50) = 11 37 nmol L on a panel of cancer cell
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